cees dekker Things To Know Before You Buy
cees dekker Things To Know Before You Buy
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Rotary motion of DNA rotors on nanopores. Major row: raw video with the Cy5 channel of each rotor. Center row: corresponding single-particle localization success of equally finishes on the DNA rotors. The position of the present frame is marked as orange and blue dots, as well as trajectory of the 10 frames right before The present body is proven as good lines.
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‘It absolutely was simply just a subject of selecting up a guide on mobile biology and beginning to go through. I'd originate from a globe of extremely-superior vacuums, cryostats and quantum phenomena, and now I was working at place temperature with molecular biology kits.
Our work was quickly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
This yielded a breakthrough. In just just a few months, we were in the position to measure transportation via someone single-walled carbon nanotube. Based upon reduced-temperature experiments by a superb PhD college student in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with incredibly lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
‘Initially we looked at Organic units having a Bodily watch and acted on the basis from the instruments we realized. It took a few years just before we started off working far more on the large Organic issues. I then started to get in touch with it nanobiology, a expression that didn't exist at some time.
2011, initially in vitro measurements of transportation throughout an individual biomimetic nuclear pore advanced; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination
The rotors harness Power from the nanoscale h2o and ion circulation that is definitely produced by a static chemical or electrochemical prospective gradient within the nanopore, which can be established via a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Manage and run autonomously in physiological situations, suggesting ways to developing Vitality-transducing motors at nanoscale interfaces.
Resolving the move sizing in condensin-pushed DNA loop extrusion identifies ATP binding as ceesdekker being the action-creating approach
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
Later on we spoke again briefly since Dekker felt that our dialogue of his religion immediately became purely philosophical, whereas In addition, it concretely can help him in his do the job.
Visualization of unstained DNA nanostructures with Superior in-emphasis transmission electron microscopy approaches
2004, discovery of recent physics in translocation of DNA by way of nanopores; initial experimental analyze of ions conduction in nanofluidic channels; 1st electrochemistry with person one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization from the mechanical Attributes of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.